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A mouse monoclonal antibody with HLA-DR4 associated specificity
Tissue Antigens
|November 1, 1985
Summary
A novel mouse monoclonal antibody specifically targets Human Leukocyte Antigen-DR4 (HLA-DR4) positive cells. Further analysis confirms the antibody immunoprecipitates a molecule consistent with the DR type.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- Human Leukocyte Antigen (HLA) molecules play a crucial role in the immune system.
- HLA-DR antigens are important in immune regulation and disease association.
Purpose of the Study:
- To develop and characterize a novel mouse monoclonal antibody targeting HLA-DR4 positive cells.
- To confirm the identity of the antigen immunoprecipitated by the antibody.
Main Methods:
- Generation of a mouse monoclonal antibody.
- Immunoprecipitation assays.
- Gel electrophoresis analysis of immunoprecipitated antigen.
Main Results:
- The developed monoclonal antibody demonstrates reactivity with HLA-DR4 positive cells.
- Gel analysis indicates the immunoprecipitated antigen is a DR molecule.
Conclusions:
- A specific monoclonal antibody targeting HLA-DR4 has been successfully generated.
- The antibody is a valuable tool for studying HLA-DR molecules and their role in biological processes.