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Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice
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Movement Termination of Slow-Wave Sleep-A Potential Biomarker?

Yvonne Höller1, Stefanía Guðrún Eyjólfsdóttir1, Matej Rusiňák1,2

  • 1Faculty of Psychology, University of Akureyri, 600 Akureyri, Iceland.

Brain Sciences
|May 25, 2024
PubMed
Summary

Body movements ending slow-wave sleep (SWS) episodes are more frequent with longer SWS duration. A small group of patients taking Sertraline showed no SWS movement termination, suggesting potential medication effects on sleep continuity.

Keywords:
Sertralineepilepsysleep EMGsleep movementsslow-wave sleep

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Area of Science:

  • Neuroscience
  • Sleep Medicine

Background:

  • Slow-wave sleep (SWS) duration impacts sleep quality and overall health.
  • Internal cues that terminate SWS episodes are not well understood.
  • Body movements, detected via electromyography (EMG) in sleep-electroencephalography (EEG), may signal SWS termination.

Purpose of the Study:

  • To investigate SWS termination by movement as a potential biomarker.
  • To characterize the relationship between SWS movement termination and various individual and clinical factors.

Main Methods:

  • Analysis of 94 full-night EEG-EMG recordings from a video-EEG monitoring unit.
  • Visual inspection of EEG and EMG recordings to identify SWS episodes terminated by movement.
  • Multiple linear regression to predict SWS movement termination based on age, sex, SWS duration/spectra, chronotype, depression, medication, memory performance, and epilepsy characteristics.

Main Results:

  • Longer overall SWS duration was significantly associated with a higher number of SWS episodes ending in movement (t = 5.64; p = 0.001).
  • No other tested variable, including epilepsy-related factors, showed a significant relationship with SWS movement termination.
  • A small subsample (n=4) of patients taking Sertraline exhibited no SWS movement termination, significantly different from other patients and those not on medication (p < 0.001).

Conclusions:

  • SWS duration is a key factor influencing movement-terminated SWS episodes.
  • The findings suggest that SWS movement termination may serve as a biomarker for sleep continuity.
  • The observed effect of Sertraline warrants further investigation in larger cohorts to confirm its impact on sleep and medication effects.