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Updated: Jun 25, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

Serum Adiponectin Predicts COVID-19 Severity.

Vlad Pavel¹, Ulrich Räth¹, Stephan Schmid¹

¹Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious Diseases, University Hospital Regensburg, 93053 Regensburg, Germany.

|May 25, 2024

Summary

Serum adiponectin levels were lower in severe COVID-19 patients compared to moderate cases and healthy individuals. Lower adiponectin indicates potential for monitoring COVID-19 severity and critical illness.

Keywords:

C-reactive protein COVID-19 adiponectin bacterial superinfection disease severity intensive care

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Area of Science:

Endocrinology
Immunology
Infectious Diseases

Background:

Adiponectin, known for metabolic and immunoregulatory roles, has shown varied levels in inflammatory conditions.
Previous studies on adiponectin in COVID-19 patients reported conflicting results.
Understanding adiponectin's role in COVID-19 severity is crucial for biomarker development.

Purpose of the Study:

To investigate serum adiponectin levels in moderate and severe COVID-19 patients.
To determine the association between serum adiponectin and COVID-19 severity.
To explore adiponectin's potential as a biomarker for critical illness.

Main Methods:

Serum adiponectin levels were measured in 26 healthy controls, 64 moderate COVID-19 patients, and 60 severe COVID-19 patients.
Correlations between adiponectin and C-reactive protein were analyzed in moderate cases.
Adiponectin levels were compared based on treatment (dialysis, vasopressors), superinfections, and survival outcomes.

Main Results:

Severe COVID-19 patients exhibited significantly lower serum adiponectin than moderate cases and controls.
Moderate COVID-19 patients showed a positive correlation between adiponectin and C-reactive protein.
Lower adiponectin levels were observed in non-survivors compared to survivors across the cohort.

Conclusions:

Serum adiponectin levels decrease in severe COVID-19 cases.
Adiponectin may serve as a potential biomarker for assessing COVID-19 severity.
Adiponectin's utility may extend to monitoring other critical illnesses.