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Management of Insomnia01:19

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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
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Clinical Studies Using Topical Melatonin.

Giovanni Greco1, Ritamaria Di Lorenzo1, Lucia Ricci1

  • 1Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via Domenico Montesano, 49, 80131 Napoli, Italy.

International Journal of Molecular Sciences
|May 25, 2024
PubMed
Summary
This summary is machine-generated.

Topical melatonin effectively protects skin from UV damage and sunburn. However, more research is needed to confirm its benefits for anti-aging and hair growth, with some studies showing promise for alopecia.

Keywords:
anti-agingclinical studiesdermatologyhair growthmelatoninphotoprotectionskintopical applications

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Area of Science:

  • Biochemistry
  • Dermatology
  • Pharmacology

Background:

  • Melatonin, a ubiquitous molecule in plants and animals, possesses antioxidant and extracellular signaling properties.
  • While oral melatonin is common for sleep, topical applications for skin disorders are less explored.
  • This review examines clinical studies on topical melatonin for photoprotection, anti-aging, and hair growth.

Purpose of the Study:

  • To review clinical studies on topical melatonin's efficacy as a photoprotective, anti-aging, and hair growth agent.
  • To assess the methodologies and results of these studies.
  • To provide an overview of the current research landscape for topical melatonin in dermatology.

Main Methods:

  • Review of clinical studies involving topical melatonin application.
  • Analysis of study designs, including randomized, double-blind, and placebo-controlled trials.
  • Evaluation of reported outcomes for photoprotection, skin aging, and hair growth.

Main Results:

  • Strong evidence supports topical melatonin's efficacy in preventing and reducing UV-induced skin damage (dermatitis, erythema, sunburn).
  • Most studies failed to conclusively demonstrate anti-aging or hair growth benefits due to design limitations or combination therapies.
  • One study indicated potential benefits of melatonin for certain types of alopecia in women.

Conclusions:

  • Topical melatonin is a clinically effective photoprotective agent against UV radiation.
  • Further rigorous research is necessary to establish the efficacy of topical melatonin for skin anti-aging and hair loss.
  • The potential of melatonin in treating specific hair loss conditions warrants additional investigation.