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Whey Protein Isolate as a Substrate to Design Calendula officinalis Flower Extract Controlled-Release Materials
Natalia Stachowiak-Trojanowska1, Weronika Walendziak1, Timothy E L Douglas2
1Faculty of Chemistry, Nicolaus Copernicus University in Torun, ul. Gagarina 7, 87-100 Torun, Poland.
International Journal of Molecular Sciences
|May 25, 2024
Summary
This study developed novel microparticles from whey protein isolate (WPI) and calcium alginate (ALG) encapsulating Calendula officinalis extract. These microparticles, incorporated into polymer films, offer a promising platform for controlled release skin applications.
Area of Science:
- Biomaterials Science
- Cosmetic Science
- Pharmaceutics
Background:
- Natural active substances and novel formulations are key in cosmetic and pharmaceutical industries.
- Calendula officinalis extract possesses beneficial properties for skin application.
- Whey protein isolate (WPI) and calcium alginate (ALG) are suitable biopolymers for microparticle formulation.
Purpose of the Study:
- To produce microparticles of WPI and ALG containing Calendula officinalis extract.
- To incorporate these microparticles into gelatin-based films.
- To characterize the microparticles and the resulting composite films for potential skin applications.
Main Methods:
- Microparticles were produced using WPI and ALG, loaded with Calendula officinalis extract.
- Microparticle characterization included optical microscopy, size measurement, water absorption, and loading capacity.
- Film properties were assessed via mechanical testing, swelling capacity, contact angle, and moisture content.
Main Results:
- Spherical microparticles successfully encapsulated the active ingredient, with complete release within 75 minutes at 37 °C.
- Incorporation of microparticles into films reduced stiffness and tensile strength but increased ductility.
- Films with microparticles exhibited enhanced swelling ability and moisture content.
Conclusions:
- The developed microparticle-loaded films provide a stable matrix for Calendula officinalis extract.
- These materials offer protection to the active ingredient and enable controlled release for skin applications.
- This research presents a foundation for innovative cosmetic and pharmaceutical products.
