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Updated: Jun 25, 2025
12:22
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
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Characterization of FOLH1 Expression in Renal Cell Carcinoma
Eric Ovruchesky1, Elizabeth Pan1, Melis Guer1
1Division of Urologic Oncology, Department of Oncology, Moores Cancer Center, University of California San Diego, San Diego, CA 92037, USA.
Cancers
|May 25, 2024
Summary
High FOLH1 expression in renal cell carcinoma (RCC) correlates with angiogenesis and longer cabozantinib treatment duration. This finding is significant for PSMA-targeted therapies in RCC patients.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Prostate-specific membrane antigen (PSMA)-targeted agents are emerging for diagnostic and therapeutic applications.
- Understanding the expression patterns of FOLH1 (the gene encoding PSMA) in renal cell carcinoma (RCC) is crucial for leveraging these agents.
Purpose of the Study:
- To investigate the expression patterns of FOLH1 in RCC.
- To determine the impact of FOLH1 expression on RCC patient outcomes.
Main Methods:
- A pooled multi-institutional analysis of 1,724 RCC patients.
- DNA and RNA next-generation sequencing was performed.
- FOLH1 expression was categorized as high (≥75th percentile) or low (<25th percentile) based on RNA transcripts per million (TPM).
Main Results:
- FOLH1 expression was significantly higher in clear cell RCC (ccRCC) compared to non-clear cell RCC (71% vs. 19.0 TPM, p < 0.001).
- FOLH1 expression correlated with angiogenic gene expression (Spearman = 0.76, p < 0.001) and endothelial cell abundance.
- Patients with FOLH1-high ccRCC showed a longer duration of cabozantinib treatment (9.7 vs. 4.6 months, HR 0.57, p < 0.05).
Conclusions:
- FOLH1 expression patterns differ based on RCC histology and tumor site.
- FOLH1 expression is linked to angiogenesis, overall survival (OS), and extended cabozantinib treatment response in ccRCC.
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