Related Experiment Video

Updated: Jun 25, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

272

Molecular and Therapeutic Roles of Non-Coding RNAs in Oral Cancer-A Review

Vidhya Rekha Umapathy1, Prabhu Manickam Natarajan2, Bhuminathan Swamikannu3

  • 1Department of Public Health Dentistry, Dr. M.G.R. Educational and Research Institute, Thai Moogambigai Dental College and Hospital, Chennai 600107, Tamil Nadu, India.

Molecules (Basel, Switzerland)
|May 25, 2024
PubMed

Insights

Non-coding RNAs (ncRNAs) play a crucial role in oral cancer (OC) development and progression. Understanding these molecules offers new diagnostic and therapeutic strategies for this common malignancy.

Area of Science:

  • Genomics
  • Molecular Biology
  • Oncology

Background:

  • Oral cancer (OC) is a prevalent malignancy with poor survival rates, especially upon metastasis.
  • Current therapeutic advancements have not significantly improved OC outcomes.
  • Understanding OC pathophysiology is crucial for developing effective diagnostic and treatment strategies.

Purpose of the Study:

  • To elucidate the role of non-coding RNAs (ncRNAs) in oral cancer.
  • To explore the diagnostic and therapeutic potential of ncRNAs in OC.

Main Methods:

  • Review of high-throughput genome sequencing data.
  • Analysis of ncRNA expression patterns in OC.
  • Investigation of ncRNA functions in OC pathogenesis.

Main Results:

  • Dysregulated ncRNA expression is linked to OC onset, development, and treatment resistance.
  • ncRNAs are implicated in the pathophysiology of oral cancer.
  • Differential expression of ncRNAs in blood or saliva suggests diagnostic and prognostic potential.

Conclusions:

  • ncRNAs represent promising biomarkers for OC diagnosis and prognosis.
  • ncRNAs hold significant therapeutic potential for oral cancer treatment.
  • Further research into ncRNAs can advance OC management.
Keywords:
circular RNAslong non-coding RNAsmiRNAsnon-coding RNAsoral cancertherapeuticstranscripts

More Related Videos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.4K
DNA Vector-based RNA Interference to Study Gene Function in Cancer13:10

DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

20.6K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K