Dried Plasma for Major Trauma: Past, Present, and Future

Area of Science:

• Trauma Care
• Blood Products
• Hemostasis

Background:

• Uncontrollable bleeding is a leading cause of preventable death in trauma patients.
• Early blood product transfusion improves survival, but liquid plasma faces storage and thawing challenges.
• Dried plasma offers a room-temperature stable, rapidly reconstitutable alternative.

Purpose of the Study:

• To review different forms of dried plasma.
• To assess the in vitro hemostatic properties and effects of drying and storage.
• To evaluate safety, efficacy, and clinical expectations of dried plasma products.

Main Methods:

• Historical review of dried plasma development.
• In vitro characterization of hemostatic properties.
• Analysis of preclinical and clinical trial data.

Main Results:

• Dried plasma can be stored at room temperature and reconstituted quickly.
• Drying processes and storage conditions impact hemostatic properties.
• Various dried plasma products are in different stages of development with distinct profiles.

Conclusions:

• Dried plasma presents a promising solution for prehospital and remote trauma care.
• Further research and clinical trials are needed to establish safety and efficacy.
• Dried plasma has the potential to significantly improve outcomes for severely injured patients.