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The Role of Oxidative Stress and Inflammatory Parameters in Heart Failure

Karolina Wróbel-Nowicka1, Celina Wojciechowska2, Wojciech Jacheć2

  • 1Medical Laboratory of Teresa Fryda, Katowice, Laboratory Branch in Specialist Hospital in Zabrze, 10, M.C-Skłodowska St., 41-800 Zabrze, Poland.

Medicina (Kaunas, Lithuania)
|May 25, 2024
PubMed

Insights

Heart failure (HF) diagnosis relies on biomarkers like NT-proBNP. This review explores oxidative stress and inflammation markers as promising new tools for HF prognosis and treatment.

Area of Science:

  • Cardiology
  • Biomarkers
  • Pathophysiology

Background:

  • Heart failure (HF) presents significant medical and social challenges.
  • Current gold-standard biomarkers like NT-proBNP and BNP have limitations in predicting HF risks.
  • HF pathophysiology involves diverse mechanisms including oxidative stress and inflammation.

Purpose of the Study:

  • To review current knowledge on oxidative stress and inflammation parameters as biomarkers for heart failure.
  • To highlight the role of oxidative-stress-mediated inflammation in HF development.
  • To identify novel diagnostic and prognostic tools for HF patients.

Main Methods:

  • Systematic literature review.
  • Analysis of oxidative stress and inflammation parameters in HF.
  • Evaluation of diagnostic and prognostic potential of these markers.

Main Results:

  • Oxidative stress and inflammation are crucial in HF progression.
  • These biomarkers offer new insights into HF mechanisms.
  • Oxidative stress and inflammatory markers show promise for HF diagnosis and prognosis.

Conclusions:

  • Oxidative stress and inflammation are key players in heart failure.
  • Novel biomarkers related to oxidative stress and inflammation are needed.
  • These markers represent a promising avenue for improving HF management.

Keywords:
biomarkersheart failureinflammationoxidative stress

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