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The Role of Oxidative Stress and Inflammatory Parameters in Heart Failure
Karolina Wróbel-Nowicka1, Celina Wojciechowska2, Wojciech Jacheć2
1Medical Laboratory of Teresa Fryda, Katowice, Laboratory Branch in Specialist Hospital in Zabrze, 10, M.C-Skłodowska St., 41-800 Zabrze, Poland.
Medicina (Kaunas, Lithuania)
|May 25, 2024
Summary
Heart failure (HF) diagnosis relies on biomarkers like NT-proBNP. This review explores oxidative stress and inflammation markers as promising new tools for HF prognosis and treatment.
Area of Science:
- Cardiology
- Biomarkers
- Pathophysiology
Background:
- Heart failure (HF) presents significant medical and social challenges.
- Current gold-standard biomarkers like NT-proBNP and BNP have limitations in predicting HF risks.
- HF pathophysiology involves diverse mechanisms including oxidative stress and inflammation.
Purpose of the Study:
- To review current knowledge on oxidative stress and inflammation parameters as biomarkers for heart failure.
- To highlight the role of oxidative-stress-mediated inflammation in HF development.
- To identify novel diagnostic and prognostic tools for HF patients.
Main Methods:
- Systematic literature review.
- Analysis of oxidative stress and inflammation parameters in HF.
- Evaluation of diagnostic and prognostic potential of these markers.
Main Results:
- Oxidative stress and inflammation are crucial in HF progression.
- These biomarkers offer new insights into HF mechanisms.
- Oxidative stress and inflammatory markers show promise for HF diagnosis and prognosis.
Conclusions:
- Oxidative stress and inflammation are key players in heart failure.
- Novel biomarkers related to oxidative stress and inflammation are needed.
- These markers represent a promising avenue for improving HF management.
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