Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ascorbic acid reduces the dopamine depletion induced by MPTP.

G C Wagner, M F Jarvis, R M Carelli

    Neuropharmacology
    |December 1, 1985
    PubMed
    Summary

    MPTP causes dopamine loss in mice, but not serotonin loss. Ascorbic acid helps protect against this dopamine depletion, suggesting a potential neuroprotective mechanism.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Decreased maternal behavior and anxiety in ephrin-A5<sup>-/-</sup> mice.

    Genes, brain, and behavior·2016
    Same author

    A selective α2 B adrenoceptor agonist (A-1262543) and duloxetine modulate nociceptive neurones in the medial prefrontal cortex, but not in the spinal cord of neuropathic rats.

    European journal of pain (London, England)·2014
    Same author

    The Concise Guide to PHARMACOLOGY 2013/14: overview.

    British journal of pharmacology·2014
    Same author

    Spinal microglial activation in rat models of neuropathic and osteoarthritic pain: an autoradiographic study using [3H]PK11195.

    European journal of pain (London, England)·2012
    Same author

    Cue-evoked dopamine release in the nucleus accumbens shell tracks reinforcer magnitude during intracranial self-stimulation.

    Neuroscience·2010
    Same author

    The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shell.

    Neuroscience·2010

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Toxicology

    Background:

    • 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin known to induce Parkinsonism.
    • Dopaminergic neurons in the striatum are particularly vulnerable to MPTP toxicity.
    • The role of oxidative stress in MPTP neurotoxicity is an area of ongoing research.

    Purpose of the Study:

    • To investigate the effects of MPTP on striatal dopamine and serotonin concentrations in a mouse model.
    • To determine if ascorbic acid can mitigate the neurotoxic effects of MPTP on dopaminergic neurons.
    • To explore potential mechanisms underlying MPTP-induced neurotoxicity.

    Main Methods:

    • Administration of MPTP to mice.
    • Measurement of striatal dopamine and serotonin levels.
    • Co-administration of ascorbic acid with MPTP.

    Main Results:

    • MPTP caused a significant and persistent depletion of striatal dopamine.
    • Striatal serotonin concentrations remained unaffected by MPTP administration.
    • Ascorbic acid significantly attenuated the MPTP-induced dopamine depletion.

    Conclusions:

    • MPTP selectively targets dopaminergic pathways in the striatum.
    • Ascorbic acid exhibits neuroprotective properties against MPTP toxicity.
    • These findings suggest a role for oxidative stress and highlight the potential therapeutic benefit of antioxidants in MPTP-induced neurodegeneration.

    Related Experiment Videos