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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Sarcopenia is a possible risk factor for amputation after peripheral arterial interventions.

Mustafa Dağlı1, Enis Burak Gül2, Görkem Yiğit3

  • 1Department of Radiology, Ankara Bilkent City Hospital, Ankara, Türkiye.

Vascular
|May 25, 2024
PubMed
Summary

Sarcopenia, a loss of muscle mass, is linked to higher mortality and amputation rates in patients undergoing endovascular therapy for peripheral arterial disease (PAD). This finding highlights sarcopenia as a critical risk factor for poor outcomes in PAD patients.

Keywords:
amputationendovascular revascularizationmortalitysarcopenia

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Area of Science:

  • Vascular Surgery
  • Geriatric Medicine
  • Radiology

Background:

  • Sarcopenia is associated with adverse outcomes in vascular diseases.
  • Peripheral arterial disease (PAD) impacts limb viability and systemic health.
  • Endovascular therapy (EVT) is a common treatment for PAD.

Purpose of the Study:

  • To investigate the association between sarcopenia and clinical outcomes in patients with PAD.
  • To evaluate the impact of sarcopenia on amputation rates and survival following EVT.

Main Methods:

  • Retrospective study of 100 PAD patients undergoing EVT.
  • Sarcopenia assessment using computed tomography angiography muscle measurements.
  • Comparison of mortality, amputation rates, and survival between sarcopenic and non-sarcopenic groups.

Main Results:

  • Sarcopenic patients had significantly higher mortality rates (65.7% vs. 20%, p < .001).
  • Major amputation rates were substantially higher in the sarcopenia group (57.1% vs. 15.4%, p < .001).
  • Sarcopenia was independently associated with major amputation (HR, 0.52; p = 0.15) and linked to reduced survival (p < .001).

Conclusions:

  • Sarcopenia is a significant risk factor for major amputation in PAD patients treated with EVT.
  • Sarcopenia is associated with increased mortality and poorer overall survival in patients with PAD.