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Updated: Jun 25, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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α5-nAChR/ADAM10 signaling mediates nicotine-related cutaneous melanoma progression via STAT3 activation

Xiangying Li1, Xianguang Meng1, Huiping Fan2

  • 1Department of Dermatology, Central Hospital Affiliated to Shandong First Medical University, 105 Jiefang Street, Jinan, 250013, China.

Archives of Dermatological Research
|May 25, 2024
PubMed
Summary

Nicotine promotes skin cutaneous melanoma (SKCM) progression by activating the α5-nicotinic acetylcholine receptor (α5-nAChR) and ADAM10 signaling pathway. This pathway enhances cancer stemness and migration, leading to poorer patient survival.

Keywords:
ADAM10Cutaneous melanomaJAK2/STAT3Nicotineα5-nAChR

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