Synthesis of 3-(4,4-dimethyl-2-piperidon-6-yl)methyl-2-pyrazoline derivatives

The results of studies of condensation of 1-(4,4-dimethyl-2-piperidon-6-yl)-4-phenyl-3-buten-2-one and its derivatives substituted in the benzene ring (R = 4-CH3 and R = 4-Cl) with hydrazine and its methyl or phenyl derivative are described. Compounds 2a, 2c and 2g were tested for their possible action on the central nervous system. Two drugs: 2c and 2g decreased locomotor activity. None of the examined compounds inhibited the reserpine-induced hypothermia, 5-HT syndrome and convulsions induced by pentetrazole in mice. Compound 2c injected only intraperitoneally depressed the number of the writhing episodes induced by p-phenylbenzoquinone.