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Related Experiment Video

Updated: Jun 25, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Complement decay-accelerating factor inhibits inflammation-induced myopia development.

Yung-Lan Chou1, Yu-An Hsu2, Chi-Fong Lin3

  • 1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan.

Molecular Immunology
|May 25, 2024
PubMed
Summary
This summary is machine-generated.

This study reveals that lower levels of CD55 (decay-accelerating factor) are linked to myopia development. Restoring CD55 levels may inhibit myopia progression by reducing inflammation and complement activation in the eye.

Keywords:
CD55Complementary systemInflammationMyopiaRetinadecay-accelerating factor (DAF)

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Area of Science:

  • Ophthalmology
  • Immunology
  • Molecular Biology

Background:

  • Myopia is a global epidemic ocular disease associated with inflammation.
  • CD55 (decay-accelerating factor) regulates complement activation and is implicated in inflammatory diseases.
  • Dysregulation of CD55 may contribute to the pathogenesis of myopia.

Purpose of the Study:

  • To investigate the association between CD55 and myopia.
  • To determine if CD55 can inhibit myopia development by suppressing ocular inflammation.
  • To explore the role of complement activation in myopia.

Main Methods:

  • Utilized three animal models: monocular form-deprivation, TNF-α-induced myopia, and allergic conjunctivitis.
  • Analyzed CD55 levels in tears from 38 human participants with varying spherical equivalents.
  • Administered CD55-Fc to eyelids in animal models and assessed ocular parameters.

Main Results:

  • Decreased CD55 and increased complement C3/C5 levels were observed in myopic and allergic conjunctivitis models.
  • CD55 expression increased with anti-inflammatory drug administration in myopia models.
  • Lower CD55 levels correlated with reduced diopter values in human myopia patients.
  • CD55-Fc administration inhibited axial elongation and refractive error changes, reducing C3/C5 and myopia-specific cytokines.

Conclusions:

  • CD55 plays a protective role in myopia development.
  • CD55 inhibits myopia progression by suppressing complement activation and subsequent ocular inflammation.
  • CD55 represents a potential therapeutic target for myopia control.