CircRNA Interference Pathway: A New Target for Intervention in Different Stages of Heart Failure

Area of Science:

• Cardiovascular Science
• Molecular Biology
• Biochemistry

Background:

• Cardio-cerebrovascular diseases and heart failure (HF) are increasing globally.
• HF pathogenesis involves inflammation, fibrosis, and oxidative stress, with unique expression patterns.
• Circular RNAs (circRNAs) are implicated in various diseases and may play a role in HF.

Purpose of the Study:

• To review circRNA biogenesis and biological functions.
• To highlight specific circRNAs associated with different stages of HF.
• To explore the potential of circRNAs as biomarkers and therapeutic targets for HF.

Main Methods:

• Literature review of circRNA mechanisms and functions.
• Identification of key circRNAs at early, progressive, and end stages of HF.
• Discussion of circRNA's role in HF pathogenesis and therapeutic development.

Main Results:

• CircRNAs exhibit distinct expression patterns across HF stages.
• Examples include CircSLC8A1-1 and CircRNA_000203 in early HF.
• CircRNA PAN3 and CircRNA (ACR) in progressive HF, and CircHIPK3 and CircNfix in end-stage HF.

Conclusions:

• CircRNAs are involved in the mechanisms of heart failure.
• CircRNAs can serve as diagnostic markers for different HF stages.
• CircRNAs offer potential as targets for novel HF drug discovery and development.