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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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Related Experiment Video

Updated: Jun 25, 2025

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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Circadian rhythms mediate malaria transmission potential.

Inês Bento, Brianna Parrington, Rushlenne Pascual

    Biorxiv : the Preprint Server for Biology
    |May 27, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Mosquitoes exhibit daily rhythms in feeding and gene expression, influencing malaria transmission. This circadian control impacts both the Anopheles mosquito and Plasmodium parasite, suggesting an evolutionary link.

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    Area of Science:

    • Parasitology
    • Chronobiology
    • Vector Biology

    Background:

    • Malaria transmission relies on infected Anopheles mosquitoes feeding on hosts.
    • Mosquitoes display 24-hour activity patterns, suggesting potential circadian regulation of behaviors like blood feeding.

    Approach:

    • Investigated circadian control in mosquito salivary glands and Plasmodium sporozoites.
    • Analyzed mosquito salivary gland and sporozoite transcriptomes for daily rhythmic gene expression.
    • Monitored mosquito feeding behavior and bloodmeal size throughout a 24-hour cycle.

    Key Points:

    • Approximately 50% of the mosquito salivary gland transcriptome shows circadian rhythmic expression, including genes vital for blood feeding.
    • Mosquitoes exhibit a preference for nighttime feeding, with cyclical variations in bloodmeal volume.
    • A significant portion of the Plasmodium sporozoite transcriptome also displays daily rhythms, including genes related to motility.

    Conclusions:

    • The study reveals robust daily rhythms in mosquito salivary glands and Plasmodium sporozoites, challenging the notion of quiescent sporozoites.
    • Circadian regulation influences mosquito blood-feeding behavior and parasite gene expression, impacting malaria transmission dynamics.
    • Findings suggest a complex, evolutionarily conserved circadian relationship between the mosquito vector, Plasmodium parasite, and mammalian host.