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Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic
Shuxuan Zheng1, Lidewij L W Rümke1, Bruno Tello Rubio1
1Department of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.
Open Forum Infectious Diseases
|May 27, 2024
Abstract:
We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.

