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Updated: Jun 25, 2025

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Published on: June 29, 2015
Maggot Kinase and Natural Thrombolytic Proteins
Can Liu1, Kaixin Zhang1, Shihao Zhang1
1Key Laboratory for Northern Urban Agriculture of Ministry of Agriculture and Rural Affairs of China, Beijing University of Agriculture, Beijing 102206, PR China.
Abstract:
Thrombolytic enzymes constitute a class of proteases with antithrombotic functions. Derived from natural products and abundant in nature, certain thrombolytic enzymes, such as urokinase, earthworm kinase, and streptokinase, have been widely used in the clinical treatment of vascular embolic diseases. Fly maggots, characterized by their easy growth and low cost, are a traditional Chinese medicine recorded in the Compendium of Materia Medica. These maggots can also be used as raw material for the extraction and preparation of thrombolytic enzymes (maggot kinase). In this review, we assembled global research reports on natural thrombolytic enzymes through a literature search and reviewed the functions and structures of natural thrombolytic enzymes to provide a reference for natural thrombophilic drug screening and development.
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