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Follicular lymphoma regulatory T-cell origin and function.

Stéphane Rodriguez1, Mehdi Alizadeh2, Claire Lamaison1

  • 1Unité Mixte de Recherche (UMR)1236, Université Rennes, INSERM, Etablissement Français du Sang Bretagne, Equipe Labellisée Ligue Contre le Cancer, Rennes, France.

Frontiers in Immunology
|May 27, 2024
PubMed
Summary

This study reveals that follicular regulatory T cells (Tfr) in Follicular Lymphoma (FL) exhibit a regulatory program and can inhibit malignant Tfh and CD8+ T cells. These Tfr cells originate from precursors shared with FL Tfh cells, offering new insights into FL pathogenesis.

Keywords:
TCR repertoirefollicular helper T cellsfollicular lymphomafollicular regulatory T cellsregulatory T cells

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