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Vascular Spasm

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...

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Related Experiment Video

Updated: Jun 25, 2025

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

Published on: December 31, 2017

Cerebrovascular Reactivity Following Spinal Cord Injury.

Alexander Mark Weber^1,2,3,4, Tom E Nightingale^5,6,7, Michael Jarrett⁸

¹Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Topics in Spinal Cord Injury Rehabilitation

|May 27, 2024

Summary

This summary is machine-generated.

Spinal cord injury (SCI) impacts cerebrovascular reactivity (CVR), with longer CVR components observed in SCI individuals. Longer time since injury and hypotensive episodes are linked to poorer CVR outcomes.

Keywords:

blood pressure functional magnetic resonance imaging spinal cord injuries steady state cerebrovascular reactivity tau

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Area of Science:

Neuroscience
Cardiovascular Science
Medical Imaging

Background:

Spinal cord injuries (SCI) are frequently associated with cardiovascular complications, elevating the risk of stroke and cognitive impairment.
Understanding the impact of SCI on cerebrovascular health is crucial for managing associated risks.

Purpose of the Study:

To assess cerebrovascular reactivity (CVR) in individuals with SCI compared to non-injured controls.
To investigate the relationship between CVR, time since injury, and cardiovascular parameters in SCI.

Main Methods:

Functional magnetic resonance imaging (fMRI) was employed to measure CVR during a hypercapnic challenge.
Participants included 8 individuals with SCI and 6 healthy controls.
CVR was quantified by analyzing fMRI signal changes.

Main Results:

SCI participants exhibited a significantly longer CVR component (tau) in grey matter compared to controls.
Time since injury (TSI) negatively correlated with steady-state CVR in grey matter and brainstem.
Lower diastolic blood pressure and a higher frequency of hypotensive episodes were associated with reduced CVR in SCI individuals.

Conclusions:

Preliminary findings indicate altered dynamic CVR in individuals with SCI, potentially contributing to their increased cerebrovascular health burden.
Further research is warranted to confirm these associations and explore causal relationships between SCI, CVR, and cardiovascular factors.