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Association between serum galectin-3 and chronic obstructive pulmonary disease: A meta-analysis
Xiangyu Zhao1, Bo Han1, Wentao Tang2
1Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Clinical Laboratory, The People's Hospital of Chizhou, Chizhou, China.
Serum galectin-3 levels are elevated in patients with chronic obstructive pulmonary disease (COPD). These levels are even higher during acute exacerbations of COPD (AECOPD), indicating galectin-3
Area of Science:
- Biochemistry and Molecular Biology
- Pulmonology
- Medical Diagnostics
Background:
- Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition with significant global health implications.
- Biomarkers are crucial for understanding COPD pathogenesis and identifying disease activity.
Purpose of the Study:
- To investigate the association between serum galectin-3 levels and COPD.
- To evaluate the relationship between serum galectin-3 and acute exacerbations of COPD (AECOPD).
Main Methods:
- A meta-analysis of twelve case-control observational studies.
- Data was pooled using a random-effects model to account for heterogeneity.
- Studies were systematically retrieved from major scientific databases.
Main Results:
- Patients with COPD exhibited significantly higher serum galectin-3 levels compared to healthy controls (SMD 0.60, P < 0.001).
- Serum galectin-3 levels were significantly elevated in patients experiencing AECOPD versus stable COPD (SMD 0.33, P < 0.001).
- Subgroup analyses did not alter these primary findings.
Conclusions:
- Elevated serum galectin-3 is associated with COPD.
- Increased serum galectin-3 levels may serve as a marker for acute exacerbations in COPD patients.
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