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The SEQANAL and SEQTALK programs: a new method of access to high-resolution nucleotide sequence comparison and
L Burnett1, A Basten, W J Hensley
1Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Computer Applications in the Biosciences : CABIOS
|December 1, 1985
Summary
Biologists can now analyze nucleotide sequences remotely using SEQANAL and SEQTALK. These programs enable high-resolution comparison and detection of sequence features on mainframe computers with minimal user resources.
Area of Science:
- Bioinformatics
- Computational Biology
- Molecular Biology
Background:
- Biologists require advanced computational tools for high-resolution analysis and comparison of nucleotide sequence data.
- Existing methods may lack accessibility or require significant local computing resources.
Purpose of the Study:
- To introduce a novel access method for nucleotide sequence analysis.
- To present a tandem program system (SEQANAL and SEQTALK) for remote sequence data analysis.
Main Methods:
- Development of SEQANAL for identifying internal repeats, dyad symmetries, homology, complementarity, and optimal alignments.
- Implementation of three established algorithms (Staden, Korn et al., Queen and Korn) and a new exhaustive tree-searching algorithm (Burnett et al.).
- Creation of SEQTALK as a portable, interactive front-end for controlling SEQANAL operations.
Main Results:
- The SEQANAL and SEQTALK system allows remote analysis on mainframe computers.
- Users with minimal computing facilities can control complex sequence analyses from a distance.
- The system operates without requiring networking facilities.
Conclusions:
- The SEQANAL/SEQTALK system provides an accessible and efficient solution for remote nucleotide sequence analysis.
- This approach empowers biologists to perform sophisticated sequence comparisons and feature detection.
- The method enhances the utility of mainframe computing for molecular biology research.