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Causal relationships between gut microbiota and lymphoma: a bidirectional Mendelian randomization study
Jing Liang1, Gengqiu Liu2, Wenqing Wang1
1Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Frontiers in Cellular and Infection Microbiology
|May 28, 2024
Summary
This study explored the causal link between gut bacteria and lymphoma. Findings suggest specific gut microbiota compositions may influence lymphoma development, offering new avenues for prevention and treatment.
Area of Science:
- Microbiome Research
- Oncology
- Genetics
Background:
- Emerging evidence suggests a link between gut microbiota and lymphoma development.
- The precise nature of this gut microbiota-lymphoma relationship is not well understood.
- This study investigates a potential causal association.
Purpose of the Study:
- To determine if a causal relationship exists between gut microbiota and lymphoma.
- To explore this association across various lymphoma subtypes.
Main Methods:
- Utilized a bidirectional two-sample Mendelian randomization (MR) approach.
- Employed inverse variance weighted (IVW) as the primary MR analysis method.
- Utilized MR-Egger, weighted median, and weighted mode for supplementary analysis.
- Assessed pleiotropy and heterogeneity using Cochrane Q, MR-PRESSO, and MR-Egger intercept tests.
- Conducted reverse MR analysis to investigate reverse causality.
Main Results:
- Identified 36 significant causal relationships between genetic liabilities of gut microbiota and lymphoma subtypes.
- MR-PRESSO and MR-Egger regression tests found no evidence of pleiotropy.
- Cochran's Q test indicated a lack of significant heterogeneity.
Conclusions:
- The Mendelian randomization analysis revealed significant causal associations between gut microbiota and lymphoma.
- These findings provide novel insights into the role of gut microbiota in lymphoma.
- Offers potential new strategies for lymphoma prevention and management.
