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Biomimetic total syntheses of renifolin F and antiarone K
Jarish Ahamad1, Faiz Ahmed Khan1
1Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, 502284, India. faiz@chy.iith.ac.in.
Abstract:
The first biomimetic and concise racemic total syntheses of renifolin F and antiarone K, accomplished in 8 and 7 linear steps, respectively, are presented in this article. Our synthetic approach commences with substituted aldehydes to produce prenylated aldol products followed by ene-type intramolecular cyclization affording a five-member core ring. This key step mediated by InCl3·4H2O is a novel procedure first utilized in prenylated systems which directly culminates mainly into tertiary alcohols.
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