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Updated: Jun 25, 2025
09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
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Microbiota and Gut-Liver Axis: An Unbreakable Bond?
Saraswathy Sivaprasadan1, K N Anila1, Krishnanunni Nair1
1Department of Gastrointestinal Surgery and Solid Organ Transplantation, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, India.
Current Microbiology
|May 28, 2024
Summary
The gut microbiota, comprising trillions of microbes, significantly impacts human health and disease. This review explores the gut-liver axis and microbial modulation strategies for liver disease management.
Area of Science:
- Microbiology
- Gastroenterology
- Human Genetics
Background:
- The human gut hosts approximately 10^14 microbes, collectively forming a microbiome with a genetic capacity exceeding the human genome.
- Emerging evidence highlights a bidirectional relationship between human and microbial genes, influencing metabolism, immunity, and gut endocrine function.
- The gut microbiota is increasingly implicated in various chronic diseases, particularly liver ailments, though direct scientific evidence remains limited.
Purpose of the Study:
- To review the epidemiology and formation of gut microbiota.
- To examine the gut-liver axis and its connection to liver disease development and progression.
- To summarize current research on modulating gut microbiota for liver disease treatment.
Main Methods:
- This is a narrative review synthesizing existing scientific literature.
- The review discusses epidemiological data on gut microbiota.
- It explores the gut-liver axis and therapeutic modulation strategies.
Main Results:
- Gut microbiota play crucial roles in human metabolism and disease.
- A strong link exists between gut microbiota and liver diseases.
- Modulating gut microbiota presents potential therapeutic avenues for liver conditions.
Conclusions:
- The gut microbiota is integral to human health and disease pathogenesis.
- The gut-liver axis is a critical pathway influencing liver health.
- Targeting the gut microbiota offers promising strategies for managing liver diseases.
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