Related Experiment Video
Updated: Jun 25, 2025
10:42
A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
9.6K
[Features of olfactory impairment connected with trigeminal nerve system]
A I Kryukov1,2, N L Kunelskaya1,2, Z O Zaoeva1
1Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia.
Vestnik Otorinolaringologii
|May 28, 2024
Summary
COVID-19 can cause olfactory dysfunction, impacting the trigeminal nerve system. Some patients experience smell loss and anxiety, suggesting a functional component requiring psychotherapeutic referral.
Area of Science:
- Neurology
- Otorhinolaryngology
- Psychiatry
Background:
- COVID-19 (coronavirus disease 2019) is known to cause olfactory dysfunction.
- Impairment of the olfactory nerve system is a primary concern, with limited data on trigeminal nerve system involvement.
Purpose of the Study:
- To qualitatively assess olfactory disorders post-COVID-19, focusing on both olfactory and trigeminal nerve systems.
- To specifically evaluate the functional component of olfactory dysfunction.
Main Methods:
- Neurological and otorhinolaryngological examinations were performed on 40 patients (aged 19-66) who had COVID-19.
- Olfactometry and the Hospital Anxiety and Depression Scale were utilized to assess olfactory function and psychological status.
Main Results:
- 52.5% of patients experienced hyposmia (reduced smell) and 12.5% anosmia (loss of smell).
- Patients with olfactory dysfunction showed a higher prevalence of anxiety-depressive disorders.
- A tendency towards identifying unpleasant or irritating odors suggests trigeminal nerve system involvement.
Conclusions:
- Functional olfactory disorders (anosmia/hyposmia) in post-COVID-19 patients may require psychotherapeutic intervention.
- Olfactory dysfunction following COVID-19 could be linked to the trigeminal nerve system.
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