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Updated: Jun 25, 2025
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
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Long non-coding RNAs expression and regulation across different brain regions in primates
Mohit Navandar1, Constance Vennin2,3, Beat Lutz2,3
1Institute for Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. navmohit@uni-mainz.de.
Scientific Data
|May 28, 2024
Summary
Long non-coding RNAs (lncRNAs) show distinct expression patterns in primate brains, influencing neural regulation and brain evolution. This study reveals lncRNA roles in human and non-human primate brain differences.
Area of Science:
- Genomics
- Neuroscience
- Evolutionary Biology
Background:
- Human and non-human primates share similar genomes but exhibit significant differences in brain-based processes like cognition.
- The functional roles of protein-coding genes are well-understood, but non-coding RNAs, particularly long non-coding RNAs (lncRNAs), remain largely unexplored in primate brain evolution.
Purpose of the Study:
- To predict and analyze the expression patterns of long non-coding RNAs (lncRNAs) across various brain regions in humans and non-human primates.
- To investigate the genomic features and evolutionary differences of shared and unique lncRNAs between species.
- To explore the regulatory roles of lncRNAs in gene expression and their contribution to species-specific brain characteristics.
Main Methods:
- Prediction and comparative analysis of lncRNAs in human, chimpanzee, gorilla, and gibbon brains.
- Differential expression analysis of orthologous lncRNAs between humans and chimpanzees across distinct brain regions.
- Co-expression network analysis of lncRNAs with protein-coding genes to identify regulatory interactions.
Main Results:
- Identification of shared orthologous and non-orthologous lncRNAs with notable genomic differences.
- Distinct expression patterns of orthologous lncRNAs in human and chimpanzee subcortical and neocortical brain regions, with conserved expression in the cerebellum.
- Increased co-expression of lncRNAs and protein-coding genes in human neocortical regions compared to chimpanzees, highlighting species-specific regulatory networks.
Conclusions:
- lncRNAs play a significant role in shaping the gene regulatory landscape of primate brains.
- Differential lncRNA expression and co-regulation contribute to neural and cognitive differences between humans and other primates.
- This study provides a valuable resource for understanding primate brain lncRNAs and their impact on brain evolution.
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