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Serum osteoprotegerin and its gene polymorphisms in patients with Takayasu's arteritis: a bicentric cross-sectional

Camila da Silva Cendon Duran1, Valéria de Falco Caparbo1, Mittermayer Barreto Santiago2

  • 1Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Advances in Rheumatology (London, England)
|May 28, 2024
PubMed

Insights

Osteoprotegerin (OPG) did not emerge as a reliable biomarker for cardiovascular disease (CVD) risk in Takayasu

Area of Science:

  • Rheumatology and Immunology
  • Cardiovascular Medicine
  • Biomarker Discovery

Background:

  • Takayasu's arteritis (TAK) patients face increased risks of metabolic syndrome and cardiovascular diseases (CVD).
  • Validated biomarkers for assessing CVD risk in TAK patients are currently lacking.
  • Osteoprotegerin (OPG) has been previously associated with atherosclerosis and poor prognosis in CVD.

Purpose of the Study:

  • To investigate serum OPG levels and OPG single nucleotide polymorphisms (SNPs) as potential biomarkers for CVD risk in TAK patients.
  • To compare OPG parameters between TAK patients and healthy controls.
  • To correlate OPG levels and SNPs with clinical data related to CVD risk.

Main Methods:

  • A bicentric cross-sectional study comparing 101 TAK patients with 93 healthy controls.
  • Measurement of serum OPG levels.
  • Genotyping of four OPG SNPs: 1181G>C (rs2073618), 245A>C (rs3134069), 163T>C (rs3102735), and 209C>T (rs3134070).
  • Association analysis of OPG parameters with clinical data and CVD risk factors.

Main Results:

  • No significant differences were found in serum OPG levels between TAK patients and controls (P=0.059).
  • Frequencies of the four studied OPG SNPs were comparable between the groups.
  • In TAK patients, serum OPG levels and OPG SNPs were not associated with CVD parameters, with a trend towards higher OPG in patients without dyslipidemia.

Conclusions:

  • Serum OPG levels and OPG SNPs do not appear to be reliable biomarkers for CVD risk in Takayasu's arteritis.
  • No significant association was found between OPG parameters and CVD risk factors in the studied TAK patient cohort.
Abstract

Keywords:
GenesOsteoprotegerinPolymorphismsTakayasu’s arteritisVasculitis

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