Related Experiment Video
Updated: Jun 25, 2025
07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
75
POST-COVID-19 INFLAMMATORY RHEUMATOID ARTHRITIS REMISSION
11Cancer Medicine, National Hospital Organization Kyoto Medical Center, Kyoto-city, Kyoto 612-8555; 2Medical R&D Promotion Project, The Japan Agency for Medical Research and Development (AMED), Chuo-ku, Tokyo 103-0022, Japan.
Georgian Medical News
|May 29, 2024
Summary
COVID-19 infection increases the risk of autoimmune rheumatic diseases. Post-COVID-19 inflammatory arthritis differs from traditional rheumatoid arthritis, suggesting new remission-focused treatments are possible.
Area of Science:
- Rheumatology
- Infectious Diseases
- Immunology
Background:
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is linked to an increased risk of autoimmune inflammatory rheumatic diseases.
- While bacterial infections can trigger rheumatoid arthritis, viral infections rarely do. Autoimmune rheumatoid arthritis typically affects adult females more than males and involves genetic factors.
- Current treatments for rheumatoid arthritis, including steroids and biologics (anti-tumor necrosis factor-α, anti-interleukin-6), alleviate symptoms but do not cure the underlying pathology.
Purpose of the Study:
- To investigate the distinct characteristics of inflammatory rheumatoid arthritis associated with COVID-19 compared to traditional autoimmune rheumatoid arthritis.
- To explore the potential for developing novel treatments aimed at achieving remission for COVID-19-related inflammatory arthritis.
Main Methods:
- Comparative analysis of clinical studies on rheumatoid arthritis triggered by infections.
- Review of current treatment strategies for rheumatoid arthritis and their efficacy in COVID-19-associated cases.
- Pathological examination of patients with post-COVID-19 inflammatory rheumatoid arthritis.
Main Results:
- Inflammatory rheumatoid arthritis associated with COVID-19 appears to have different pathogenesis, symptoms, and pathological findings compared to autoimmune rheumatoid arthritis.
- Steroid immunosuppressive treatment shows effectiveness against COVID-19-related inflammatory rheumatoid arthritis.
- COVID-19-related autoimmune-like diseases may have distinct pathological conditions from inherited autoimmune diseases.
Conclusions:
- The unique pathology of COVID-19-related inflammatory rheumatoid arthritis suggests that treatments targeting remission are a viable therapeutic strategy.
- Further pathological analyses are crucial for developing effective treatments for post-COVID-19 inflammatory rheumatoid arthritis.
- Understanding the differences between COVID-19-associated and autoimmune rheumatoid arthritis is key to advancing rheumatologic care.
More Related Videos
Related Concept Videos
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
131
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
131
01:28Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
158
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
158
01:20The JAK-STAT Signaling Pathway
8.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.8K
01:29Inflammatory Bowel Disease IV: Pharmacological Management
126
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
126
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
115
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
115