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Updated: Jun 25, 2025

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral Junceella fragilis
Hai Nhat Do1,2, Yu-Ta Chen3, Su-Ying Chien4
1Department of Marine Biotechnology and Resources, National Sun Yat-sen University Kaohsiung 804201 Taiwan.
Abstract:
The chemical screening of an octocoral identifed as Junceella fragilis has led to the isolation of five chlorinated briarane-type diterpenoids, including three known metabolites, gemmacolide X (1), frajunolide I (2), and fragilide F (3), along with two new analogs, 12α-acetoxyfragilide F (4) and 12α-acetoxyjunceellin (5). Single-crystal X-ray diffraction analysis was carried out to determine the absolute configurations of 1 and 2, while the structures of new compounds 4 and 5 were ascertained with 2D NMR experiments. Briaranes 1 and 3-5 were active in enhancing alkaline phosphatase (ALP) activity.
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