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Niels August Willer Strand1, Mette Ødegaard Nielsen1,2, Jimmi Nielsen1,2

  • 1Enhed for Kompliceret Skizofreni og Oligofreni, Københavns Universitetshospital - Psykiatrisk Center Glostrup.

Ugeskrift for Laeger
|May 29, 2024
PubMed
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Long-acting injectable antipsychotics (LAI) offer benefits over oral forms for relapse prevention. Understanding LAI pharmacokinetics is crucial for effective clinical use, dose adjustments, and treatment changes.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Clinical Pharmacy

Background:

  • Long-acting injectable antipsychotics (LAI) are vital for managing psychiatric disorders, offering improved adherence and reduced relapse rates compared to oral formulations.
  • Significant pharmacokinetic differences exist between LAI and oral antipsychotics, requiring specialized clinical knowledge.

Purpose of the Study:

  • To review key clinical characteristics of LAI.
  • To provide a framework for understanding LAI pharmacokinetics.
  • To enhance clinician knowledge regarding LAI initiation, dose modification, and discontinuation.

Main Methods:

  • Literature review of pharmacokinetic properties of LAI.
  • Synthesis of clinical data on LAI use.
  • Development of a conceptual pharmacokinetic framework.

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Main Results:

  • LAI exhibit distinct pharmacokinetic profiles influencing treatment strategies.
  • Understanding these profiles is essential for optimizing patient outcomes and managing adverse events.
  • A conceptual framework aids in predicting and managing LAI behavior in clinical practice.

Conclusions:

  • Enhanced understanding of LAI pharmacokinetics is critical for safe and effective clinical application.
  • Clinicians need this knowledge for informed treatment decisions regarding LAI.
  • This review provides a foundation for improved LAI management and patient care.