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Use of Testosterone-Lowering Medication in Patients With Intellectual Disabilities and Problematic Sexual Behaviour:
Jacob Rong Bentsen1, Torbjørn Lien Kjær2, Magnus Roland Balleby1
1Glostrup Copenhagen University Hospital, Glostrup, Denmark, gentoftehospital.dk.
Case Reports in Psychiatry
|June 8, 2026
Summary
Testosterone-lowering medication (TLM) may help reduce problematic sexual behavior in men with intellectual disabilities. However, careful monitoring is essential due to potential side effects and relapse risks after treatment cessation.
Area of Science:
- Endocrinology
- Psychiatry
- Intellectual Disability Research
Background:
- Testosterone-lowering medication (TLM) is utilized for severe paraphilic disorders and problematic sexual behavior.
- Its application in patients with intellectual disability (ID) remains under-researched.
Purpose of the Study:
- To investigate the efficacy and safety of TLM in male patients with intellectual disability.
- To understand the outcomes of TLM treatment in this specific population.
Main Methods:
- A nationwide survey was conducted to identify patients with ID receiving TLM.
- Data was collected from specialized outpatient clinics on treatment response and adverse effects.
Main Results:
- Four out of five patients experienced reduced problematic sexual behavior while on TLM.
- Three patients relapsed after discontinuing TLM.
- Observed adverse effects included osteoporosis, hypertension, depression, and suppressed sexual development.
- Regional variations in monitoring and access to TLM were noted.
Conclusions:
- TLM can be effective for carefully selected patients with intellectual disability.
- Treatment necessitates rigorous monitoring and robust ethical oversight.
- Long-term outcomes and management strategies require further investigation.
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