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Related Concept Videos

Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

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Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

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Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
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Substance Use Disorders Affecting Sleep01:24

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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Drug Dependence01:17

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Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
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Three-Compartment Open Model01:06

Three-Compartment Open Model

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The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
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Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

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In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
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Related Experiment Video

Updated: Jun 9, 2025

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
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Drug Use during Incarceration: A Comprehensive Quality and Prevalence Study in Three Danish Prisons.

Torbjørn Lien Kjær1, Peter Hindersson2, Jacob Rong Bentzen3

  • 1Danish Prison and Probation Service, Copenhagen, Denmark.

Substance Use & Misuse
|November 1, 2024
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Summary

Drug testing in Danish prisons revealed that while on-site screening was acceptable, it missed several substances. Future strategies will use broader methods to improve accuracy and detect emerging drug trends.

Keywords:
Prisondrug diversiondrug screeningdrug usenew psychoactive substancesprevalencequality control study

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Area of Science:

  • Forensic Toxicology
  • Clinical Chemistry
  • Public Health

Background:

  • Drug use in Danish prisons lacked detailed laboratory analysis.
  • A quality study was initiated by the Danish Prison and Probation Service.

Purpose of the Study:

  • Evaluate on-site drug screening performance.
  • Identify emerging drug trends in correctional facilities.
  • Propose evidence-based drug testing strategies.

Main Methods:

  • Analyzed 1952 urine samples from 710 inmates over two years.
  • Used on-site immunoassay screening and laboratory confirmation (LC-MS/MS, GC-MS).
  • Tested for 123 analytes, including drugs-of-abuse, medical drugs, metabolites, and new psychoactive substances (NPS).

Main Results:

  • On-site immunoassay showed 66-100% sensitivity and >95% accuracy.
  • Laboratory analysis detected substances missed by screening, such as tramadol, oxycodone, and GHB.
  • Prevalence order: cannabis > ethanol > cocaine > benzodiazepines > amphetamine.

Conclusions:

  • On-site screening performance was acceptable but insufficient for comprehensive detection.
  • A broader screening method is recommended for future drug testing in Danish prisons.
  • No clear trend of new psychoactive substance (NPS) use was observed.