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Updated: Jun 25, 2025
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Correlation between novel inflammatory markers and carotid atherosclerosis: A retrospective case-control study
Man Liao1, Lihua Liu1, Lijuan Bai1
1Department of General, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Insights
The neutrophil to lymphocyte platelet ratio (NLPR) is the best inflammatory marker for predicting carotid atherosclerosis, a key factor in ischemic stroke. This study analyzed novel inflammatory markers in over 10,000 patients to identify the most effective predictor.
Area of Science:
- Cardiovascular Medicine
- Inflammatory Diseases
- Stroke Prevention
Background:
- Carotid atherosclerosis is a chronic inflammatory condition and a primary cause of ischemic stroke.
- Novel inflammatory markers offer potential for better risk assessment.
Purpose of the Study:
- To evaluate the relationship between carotid atherosclerosis and several novel inflammatory markers.
- To identify the most effective inflammatory marker for predicting carotid atherosclerosis.
Main Methods:
- Analysis of 10,015 patients' data (2016-2019), with 1910 diagnosed with carotid atherosclerosis.
- Logistic regression and ROC curve analysis were used to assess marker correlation and predictive value.
Main Results:
- Platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and platelet to neutrophil ratio (PNR) were lower in patients with carotid atherosclerosis.
- Neutrophil to lymphocyte ratio (NLR), neutrophil to lymphocyte platelet ratio (NLPR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) were higher.
- NLPR demonstrated the highest predictive value (AUC=0.67) for carotid atherosclerosis.
Conclusions:
- Novel inflammatory markers are significantly associated with carotid atherosclerosis.
- The neutrophil to lymphocyte platelet ratio (NLPR) is the optimal marker for predicting carotid atherosclerosis risk.
Objective:
Carotid atherosclerosis is a chronic inflammatory disease, which is a major cause of ischemic stroke. The purpose of this study was to analyze the relationship between carotid atherosclerosis and novel inflammatory markers, including platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to neutrophil ratio (PNR), neutrophil to lymphocyte platelet ratio (NLPR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), in order to find the best inflammatory predictor of carotid atherosclerosis.
Method:
We included 10015 patients who underwent routine physical examinations at the physical examination center of our hospital from January 2016 to December 2019, among whom 1910 were diagnosed with carotid atherosclerosis. The relationship between novel inflammatory markers and carotid atherosclerosis was analyzed by logistic regression, and the effectiveness of each factor in predicting carotid atherosclerosis was evaluated by receiver operating characteristic (ROC) curve and area under the curve (AUC).
Result:
The level of PLR, LMR and PNR in the carotid atherosclerosis group were lower than those in the non-carotid atherosclerosis group, while NLR, NLPR, SII, SIRI and AISI in the carotid atherosclerosis group were significantly higher than those in the non-carotid atherosclerosis group. Logistic regression analysis showed that PLR, NLR, LMR, PNR, NLPR, SII, SIRI, AISI were all correlated with carotid atherosclerosis. The AUC value of NLPR was the highest, which was 0.67, the cut-off value was 0.78, the sensitivity was 65.8%, and the specificity was 57.3%. The prevalence rate of carotid atherosclerosis was 12.4% below the cut-off, 26.6% higher than the cut-off, and the prevalence rate increased by 114.5%.
Conclusion:
New inflammatory markers were significantly correlated with carotid atherosclerosis, among which NLPR was the optimum inflammatory marker to predict the risk of carotid atherosclerosis.
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