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Membrane attack complex of complement in dermatitis herpetiformis.

M V Dahl, R J Falk, R Carpenter

    Archives of Dermatology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    The membrane attack complex (MAC) was found in normal skin of dermatitis herpetiformis patients. These findings suggest a potential role for complement in this skin disease.

    Area of Science:

    • Immunology
    • Dermatology
    • Complement System Biology

    Background:

    • The membrane attack complex (MAC) is the terminal product of the complement cascade.
    • MAC assembly involves C9 polymerization and can cause cell membrane damage.
    • The presence of MAC in tissues suggests a potential role in inflammatory diseases.

    Purpose of the Study:

    • To investigate the presence and localization of MAC in normal-appearing skin of dermatitis herpetiformis (DH) patients.
    • To determine if MAC deposition correlates with IgA deposits characteristic of DH.

    Main Methods:

    • Skin biopsies from five DH patients were analyzed.
    • Immunohistochemistry was performed using a monoclonal antibody (poly C9-MA) specific for polymerized C9.
    • Antibody staining was compared with IgA deposition sites.

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    Main Results:

    • Granular deposits of polymerized C9 were detected in the dermal papillae of all DH patients studied.
    • These C9 deposits colocalized with sites of IgA deposition.
    • The antibody used specifically recognizes polymerized C9, indicating MAC formation.

    Conclusions:

    • Polymerized C9, a component of the membrane attack complex, is present in the normal-appearing skin of dermatitis herpetiformis patients.
    • MAC deposition occurs at sites of IgA deposition in the dermal papillae.
    • The precise pathological significance of MAC in DH remains to be elucidated.