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Methamphetamine Use Disorder and Inflammation: A Case-Control Study.
Nilifer Gürbüzer1, Mustafa Can Güler2, I Brahim Hakkı Tör3
1Department of Psychiatry, Regional Training and Research Hospital, University of Health Sciences, Erzurum, Turkey.
Psychiatry Investigation
|May 29, 2024
Summary
Methamphetamine use disorder (MUD) is linked to increased inflammation markers. Peripheral hemogram parameters, including leukocyte and platelet counts, and the systemic immune inflammation index (SII), are elevated in individuals with MUD.
Area of Science:
- Biochemistry
- Immunology
- Addiction Medicine
Background:
- Methamphetamine use disorder (MUD) is a significant global health issue associated with severe morbidity and mortality.
- Inflammation plays a critical role in the pathophysiology of MUD, necessitating the investigation of biochemical markers for monitoring and treatment.
- Understanding the inflammatory profile in MUD can provide insights into disease progression and potential therapeutic targets.
Purpose of the Study:
- To investigate the relationship between inflammatory response and MUD in adult men.
- To evaluate peripheral hemogram parameters, including leukocyte counts, subtypes, ratios, and specific inflammatory indices, in individuals with MUD compared to a control group.
- To assess the correlation between the severity of methamphetamine use and inflammatory markers.
Main Methods:
- Peripheral hemogram parameters, C-reactive protein (CRP), and systemic immune inflammation index (SII) were analyzed in 76 adult male MUD patients and 70 controls.
- Calculated ratios included neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR).
- The monocyte/high-density lipoprotein (HDL) ratio was also evaluated, alongside daily methamphetamine intake and duration of use.
Main Results:
- Patients with MUD exhibited significantly higher levels of leukocytes, platelets, neutrophils, monocytes, CRP, NLR, PLR, MLR, SII, and monocyte/HDL ratio compared to controls.
- A positive correlation was found between daily methamphetamine intake and duration of use with PCT, neutrophil count, NLR, PLR, MLR, and SII.
- Daily methamphetamine intake significantly and positively impacted SII, with each unit increase elevating SII by 165.53 units.
Conclusions:
- The study confirms the presence of peripheral subclinical inflammation in adult men with MUD.
- Elevated systemic immune inflammation index (SII) is strongly associated with methamphetamine use severity.
- These findings highlight the role of inflammation in MUD and suggest potential for inflammatory markers in clinical management.
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