Super-resolution ultrasound and microvasculomics: a consensus statement.

Area of Science:

• Medical Imaging
• Biotechnology
• Artificial Intelligence in Medicine

Background:

• Microvessel evaluation is crucial for disease assessment.
• Super-resolution ultrasound (SRUS) microvascular imaging enhances morphological and functional analysis of microcirculation.
• SRUS utilizes contrast microbubbles to improve sensitivity and spatial resolution for detailed vascular imaging.

Purpose of the Study:

• To introduce "Ultrasound microvasculomics" as a novel approach for microvessel assessment.
• To address the limitations of current SRUS quantitative parameters.
• To explore the potential of omics methods for precise microvascular evaluation.

Main Methods:

• Reviewing the development and application of Super-resolution Ultrasound (SRUS).
• Highlighting the strengths of omics methodology in addressing SRUS quantification shortcomings.
• Introducing "Ultrasound microvasculomics" for high-throughput feature extraction from SRUS images.

Main Results:

• SRUS imaging provides superior detail in vascular structures and hemodynamics compared to traditional ultrasound.
• Ultrasound microvasculomics enables high-throughput extraction of image features from SRUS.
• This approach promises more precise and personalized microvascular assessment.

Conclusions:

• Ultrasound microvasculomics is a promising novel approach for detailed microvascular analysis.
• Further validation of ultrasound microvasculomics in both preclinical and clinical settings is needed.
• This method can provide more precise and abundant micro-blood flow information in clinical medicine.