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Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
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Lactylation: the novel histone modification influence on gene expression, protein function, and disease
Yue Hu1, Zhenglin He2, Zongjun Li2
1Department of Tissues Bank, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Clinical Epigenetics
|May 29, 2024
Summary
Lactic acid, once a metabolic waste, is now known to regulate cellular processes through protein lactylation. This post-translational modification is crucial for understanding its role in both normal physiology and diseases like cancer.
Area of Science:
- Biochemistry
- Cell Biology
- Oncology
Background:
- Lactic acid was traditionally viewed as a metabolic byproduct of glycolysis.
- The Warburg effect highlighted its significance in tumor cells, linking it to angiogenesis and immune suppression.
- The molecular mechanisms behind lactic acid's non-metabolic functions were poorly understood.
Purpose of the Study:
- To provide a comprehensive overview of protein lactylation.
- To explore the discovery, regulation, and physiological roles of lactylation.
- To discuss the implications of lactylation in pathological processes.
Main Methods:
- Review of existing scientific literature on lactic acid and protein modification.
- Analysis of studies identifying "writers" and "erasers" of lactylation.
- Examination of protein lactylation patterns across species.
Main Results:
- Lactylation, a post-translational modification by lactate, regulates cellular processes.
- Potential enzymes responsible for "writing" and "erasing" lactylation have been identified.
- Protein lactylation patterns vary across different organisms and play diverse physiological roles.
Conclusions:
- Protein lactylation is a key mechanism mediating lactate's non-metabolic functions.
- Understanding lactylation offers insights into cancer biology and other pathologies.
- Further research into lactylation holds significant scientific and therapeutic potential.
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