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Updated: Jun 25, 2025

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
Published on: July 1, 2011
T-Cell/B-Cell Interactions in Atherosclerosis
Peter William Jones1, Ziad Mallat1,2, Meritxell Nus1
1Cardiovascular Division, Department of Medicine, Heart and Lung Research Institute, University of Cambridge, United Kingdom (P.W.J., Z.M., M.N.).
Abstract:
Atherosclerosis is a complex inflammatory disease in which the adaptive immune response plays an important role. While the overall impact of T and B cells in atherosclerosis is relatively well established, we are only beginning to understand how bidirectional T-cell/B-cell interactions can exert prominent atheroprotective and proatherogenic functions. In this review, we will focus on these T-cell/B-cell interactions and how we could use them to therapeutically target the adaptive immune response in atherosclerosis.
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