Smart controlled-release nanopesticides based on metal-organic frameworks

The practical utilization rates of conventional pesticide formulations by target organisms are very low, which results in the pollution of ecological environments and the formation of pesticide residues in agricultural products. Water-based nanopesticide formulations could become alternative and effective formulations to eventually resolve the main issues of conventional pesticide formulations. In this feature article, we describe the design concept of smart (stimuli-responsive) controlled-release nanopesticides, which are created toward hierarchical targets (pests, pathogens, and foliage) in response to multidimensional stimuli from physiological and environmental factors (such as sunlight) of target organisms and plants, for achieving enhanced insecticidal and fungicidal efficacies. The pore sizes and functionalities of metal-organic frameworks (MOFs) can be fine-tuned through the choice of metal-containing units and organic ligands. Tailor-made MOF nanoparticles with large microporous or mesoporous sizes, as well as good biocompatibility and high thermal, mechanical, and chemical durabilities, are used to load pesticides within these pores followed by coating of plant polyphenols and natural polymers for stimuli-responsive controlled pesticide release. This feature article highlights our works on smart controlled-release MOF-based nanopesticides and also includes related works from other laboratories. The future challenges and promising prospects of smart controlled-release MOF-based nanopesticides are also discussed.