Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

27.3K
Overview
27.3K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

271
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
271
Hypersensitivities01:30

Hypersensitivities

601
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
601
Allergic Drug Reactions01:27

Allergic Drug Reactions

833
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
833
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

766
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
766
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

276
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
276

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Copper deficiency myelopathy and sensory ataxia in a 20-year-old female.

JAAPA : official journal of the American Academy of Physician Assistants·2026
Same author

Intergenerational Trauma, Dependency, and Detachment.

The Journal of nervous and mental disease·2023
Same author

Suicidality and Implicit Dependency in Child and Adolescent Inpatients With Histories of Trauma: Moderating Effect of Gender.

The Journal of nervous and mental disease·2023
Same author

Urticaria and Angioedema.

Primary care·2023
Same author

Love in the Time of COVID-19: Experiences of a Psychology Trainee.

Psychoanalysis, self and context·2022
Same author

Impact of a Hands-on Knee Exam Workshop on Medical Student Clinical Examination Scores.

PRiMER (Leawood, Kan.)·2020
Same journal

Care Transitions Continue to Evolve.

The Medical clinics of North America·2026
Same journal

Navigating the Gaps: A Comprehensive Overview of Care Transitions Across the Continuum.

The Medical clinics of North America·2026
Same journal

Care Transitions and Value-Based Payment Models in the United States.

The Medical clinics of North America·2026
Same journal

Technology and Innovation in Care Transitions: Imagining the Future of Postdischarge Care.

The Medical clinics of North America·2026
Same journal

Primary Care, Specialists, and Hospitals: Bridging the Gaps in Communication and Coordination.

The Medical clinics of North America·2026
Same journal

Social Determinants of Health: Unique Considerations in Transitions of Care.

The Medical clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2025

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.1K

Update on Urticaria and Angioedema.

Kate Szymanski1, Paul Schaefer1

  • 1Department of Family Medicine, College of Medicine and Life Sciences at the University of Toledo Medical Center, 3333 Glendale Avenue, Toledo, OH 43614-2598, USA.

The Medical Clinics of North America
|May 30, 2024
PubMed
Summary
This summary is machine-generated.

Urticaria and angioedema stem from histamine release, diagnosed clinically. Treatment involves trigger avoidance and H1 antihistamines, with higher doses considered.

Keywords:
Acute urticariaAngioedemaAntihistaminesChronic urticaria

More Related Videos

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.4K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

445

Related Experiment Videos

Last Updated: Jun 25, 2025

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

8.1K
Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.4K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

445

Area of Science:

  • Immunology
  • Dermatology
  • Allergy

Background:

  • Urticaria and angioedema result from mast cell and basophil release of inflammatory mediators.
  • These reactions can be immunoglobulin E (IgE)-mediated or non-IgE-mediated.

Purpose of the Study:

  • To outline the diagnostic and management principles for urticaria and angioedema.
  • To emphasize clinical diagnosis and the exclusion of anaphylaxis.

Main Methods:

  • Clinical diagnosis based on patient history and physical examination.
  • Consideration of limited laboratory workup for specific underlying conditions.
  • Pharmacotherapy with second-generation H1 antihistamines.

Main Results:

  • Diagnosis is primarily clinical, requiring differentiation from anaphylaxis.
  • Trigger identification and avoidance are key management strategies.
  • H1 antihistamines are the first-line treatment, with dose titration advised.

Conclusions:

  • Effective management hinges on clinical assessment and trigger avoidance.
  • Pharmacological treatment includes H1 antihistamines, adjustable for efficacy.
  • A targeted approach to laboratory testing is recommended.