Ferroptosis: A double-edged sword.

Area of Science:

• Biochemistry
• Cell Biology
• Pathology

Background:

• Ferroptosis is programmed cell death driven by iron-dependent lipid peroxidation.
• It is characterized by iron accumulation and lipid peroxidation.
• Ferroptosis has implications in both cancer and other diseases.

Purpose of the Study:

• To review the paradoxical regulation of ferroptosis in tumors and other diseases.
• To discuss methods for inducing ferroptosis in cancer treatment.
• To explore strategies for inhibiting ferroptosis in various medical conditions.

Main Methods:

• Review of ferroptosis history, concept, and mechanisms.
• Analysis of ferroptosis induction methods in tumors.
• Examination of ferroptosis utilization and inhibition in diseases.

Main Results:

• Ferroptosis exhibits anti-cancer properties by inducing cell death in malignant cells.
• Conversely, ferroptosis can damage normal cells, contributing to disease pathogenesis.
• The regulation of ferroptosis presents key contradictions in disease control.

Conclusions:

• Understanding ferroptosis's dual role is crucial for therapeutic development.
• Targeting ferroptosis offers potential for cancer therapy and disease management.
• Further research into ferroptosis control mechanisms is warranted.