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Risk Factors for Stroke in Children with Tuberculous Meningitis: A Prospective Observational Study
Niti Prakash1, Manisha Verma2, Chandrakanta Kumar1
1Department of Pediatrics, King George's Medical University, Lucknow, UP, India.
Neurology India
|May 31, 2024
Summary
Stroke is common in children with tuberculous meningitis (TBM), affecting over half of patients. Clinical signs like altered sensorium and vomiting can predict stroke occurrence, leading to poorer outcomes.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Neuroimaging
Background:
- Tuberculous meningitis (TBM) is a serious infection affecting children.
- Stroke is a recognized complication of TBM, but its prevalence and predictors require further investigation.
Purpose of the Study:
- To determine the prevalence of stroke in pediatric TBM patients.
- To identify clinical and radiological factors associated with stroke in this population.
Main Methods:
- Prospective observational study of 78 children with TBM.
- Neuroimaging (CT/MRI) used to diagnose stroke.
- Comparison of demographic, clinical, CSF, and imaging findings between stroke and non-stroke groups.
Main Results:
- Stroke (infarction) was detected in 53.8% of TBM patients.
- Hydrocephalus (62.8%) and basal meningeal enhancement (64.1%) were common radiological findings.
- TBM patients with stroke experienced poorer clinical outcomes.
Conclusions:
- Age, altered sensorium, focal neurological deficits, vomiting, and basal meningeal enhancement are predictors of stroke in TBM.
- Early identification of stroke risk factors is crucial for management.
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