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Intra-abdominal Inflammatory Myofibroblastic Tumour (IMFT)-Uncommon Entity.

Surjeet Dwivedi¹, C R Rakesh¹, S Anand¹

¹Command Hospital Air Force, Bangalore, India.

Indian Journal of Surgical Oncology

|May 31, 2024

Summary

This summary is machine-generated.

Inflammatory myofibroblastic tumours (IMFT) are rare in the GI tract, often affecting younger individuals. This case highlights multifocal GI IMFT managed with surgery and chemotherapy, emphasizing surgical resection as primary treatment.

Keywords:

ALK Rearrangement GI tract IMFT Recurrence

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Area of Science:

Oncology
Gastroenterology
Pathology

Background:

Inflammatory myofibroblastic tumour (IMFT) is an uncommon neoplasm primarily affecting the lungs and mediastinum.
While typically seen in pediatric and young adult populations, IMFT of the gastrointestinal tract is exceptionally rare.

Observation:

This report details a rare instance of multifocal IMFT originating within the gastrointestinal tract.
The patient underwent successful gross total surgical excision followed by adjuvant chemotherapy.

Findings:

Surgical resection is the definitive treatment for gastrointestinal IMFT.
The efficacy of chemotherapy and radiation therapy is currently limited.
Tumor aetiology is largely unknown, though ALK-positivity suggests potential targeted therapy.

Implications:

Close follow-up is crucial due to the high incidence of local recurrences.
TP53 positivity, aneuploidy, and recurrent lesions are associated with increased risk of metastasis and recurrence.