Related Experiment Video

Updated: Jun 25, 2025

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

553

Association between maternal gestation weight gain and preterm birth according to pre-pregnancy body mass index and

Xiaoxiao Zhang1, Binbin Yin1, Kaiqi Wu1

  • 1Department of Laboratory Medicine, The Women's Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|May 31, 2024
PubMed

Insights

Gestational weight gain (GWG) impacts preterm birth (PTB) risk, with inadequate gain increasing risk and excessive gain reducing it. These associations vary by pre-pregnancy BMI and HbA1c levels, even within the normal range.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Public Health

Background:

  • Gestational weight gain (GWG) is a critical factor in pregnancy outcomes.
  • Preterm birth (PTB) remains a significant concern in maternal and infant health.
  • Understanding the interplay between GWG, pre-pregnancy body mass index (pp-BMI), and glycated hemoglobin (HbA1c) is crucial for PTB prevention.

Purpose of the Study:

  • To investigate the association between gestational weight gain (GWG) and preterm birth (PTB).
  • To examine how pre-pregnancy body mass index (pp-BMI) and glycated hemoglobin (HbA1c) modify the GWG-PTB relationship.
  • To identify optimal GWG strategies for PTB risk reduction across different maternal profiles.

Main Methods:

  • Population-based retrospective cohort study of 23,699 pregnant women (July 2017-January 2020).
  • Classification of GWG into inadequate, appropriate, and excessive categories.
  • Statistical analysis using odds ratios (OR) with 95% confidence intervals (CI), adjusting for confounders.

Main Results:

  • A total of 1124 (4.70%) PTBs were recorded.
  • Inadequate GWG was associated with a significantly higher risk of PTB.
  • Excessive GWG showed a reduced risk of PTB, with variations observed based on pp-BMI and HbA1c levels.

Conclusions:

  • Significant association exists between GWG and PTB risk, modulated by pp-BMI and HbA1c.
  • Appropriate GWG is essential for preventing PTB.
  • Elevated HbA1c levels within the normal range warrant attention for PTB risk management.
Abstract

Keywords:
Gestational weight gainHbA1cpre-pregnancy body mass indexpreterm birth

More Related Videos

External Cephalic Version: Is it an Effective and Safe Procedure?08:49

External Cephalic Version: Is it an Effective and Safe Procedure?

Published on: June 6, 2020

14.5K
Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

595

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
920
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
453
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
523
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K