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Updated: Oct 9, 2026

Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
Published on: March 8, 2012
La Crosse virus G1 glycoprotein undergoes a conformational change at the pH of fusion
Abstract:
La Crosse virus, a member of the family Bunyaviridae, can mediate cell-to-cell fusion after mild acidification. Either of its two envelope glycoproteins could potentially be responsible for this function. The large glycoprotein (G1) undergoes a conformational change at the pH of activation of the fusion function, resulting in both an alteration in the cleavage pattern produced by amino-acid-specific proteases, and in a change in its antigenicity, as defined by altered binding of monoclonal antibodies.
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