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Genetically Predicted Sleep Traits and Sensorineural Hearing Loss: A Mendelian Randomization Study.
Yan Gao1,2,3, Yuanzheng Qiu1,2,3,4, Shanhong Lu1,2,3,4
1Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
The Laryngoscope
|May 31, 2024
Summary
Morning chronotype and daytime sleepiness may causally contribute to sensorineural hearing loss (SNHL). Optimal sleep could help prevent SNHL, but SNHL does not appear to cause sleep issues.
Area of Science:
- Genetics
- Sleep Medicine
- Otolaryngology
Background:
- Observational studies suggest links between sleep and sensorineural hearing loss (SNHL), including sudden SNHL (SSNHL).
- Causal evidence for these associations remains limited.
Purpose of the Study:
- To investigate the potential causal relationships between sleep traits and SNHL/SSNHL.
- To clarify the directionality of these associations using a robust genetic approach.
Main Methods:
- A two-sample Mendelian randomization (MR) analysis was employed.
- Utilized summary data from large Genome-Wide Association Studies (UK Biobank and FinnGen).
- Primary analysis used the inverse-variance weighted (IVW) method, with extensive sensitivity analyses for robustness.
Main Results:
- Morning chronotype showed a suggestive causal association with SNHL onset (OR=1.08).
- Daytime sleepiness was causally associated with SNHL onset (OR=1.88).
- Morning chronotype was also nominally associated with sudden SNHL (SSNHL) onset (OR=1.37).
- No evidence of a causal effect of SNHL/SSNHL on sleep traits was found.
Conclusions:
- Morning chronotype and daytime sleepiness appear to be causal contributors to SNHL.
- These findings suggest that optimizing sleep may play a role in SNHL prevention.
- The study highlights the importance of sleep health in audiological well-being.
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