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[How do 2'-O-methylations within Human Immunodeficiency Virus type 1 (HIV-1) genome regulate its replication?]

Alice Decombe1, Priscila El-Kazzi1, Sébastien Nisole1

  • 1AFMB (Architecture et fonction des macromolécules biologiques), UMR 7257 - CNRS / Université Aix-Marseille, Marseille, France.

Medecine Sciences : M/S
|May 31, 2024
PubMed
Summary

HIV-1 RNA modifications called 2''-O-methylations, added by FTSJ3, have dual effects. They protect the virus from immune sensors like MDA5 but also hinder viral replication, suggesting a complex role in HIV-1 infection.

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