Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Glomerular ultrafiltration dynamics: historical perspective.

W J Arendshorst, C W Gottschalk

The American Journal of Physiology

|February 1, 1985

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Calcium handling in afferent arterioles.

Acta physiologica Scandinavica·2004

Same author

Norepinephrine-induced calcium signaling pathways in afferent arterioles of genetically hypertensive rats.

American journal of physiology. Renal physiology·2001

Same author

Alpha1-adrenoceptor subtypes on rat afferent arterioles assessed by radioligand binding and RT-PCR.

American journal of physiology. Renal physiology·2001

Same author

Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics.

American journal of physiology. Heart and circulatory physiology·2000

Same author

Ryanodine receptor and capacitative Ca2+ entry in fresh preglomerular vascular smooth muscle cells.

Kidney international·2000

Same author

EP(1) and EP(4) receptors mediate prostaglandin E(2) actions in the microcirculation of rat kidney.

American journal of physiology. Renal physiology·2000

Same journal

Blood coagulation in fish.

The American journal of physiology·2011

Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010

Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010

Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010

Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010

Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010

See all related articles

The renal glomerulus

Area of Science:

Nephrology
Physiology
Renal Physiology

Background:

The renal glomerulus, first described in 1666, has a complex history of research regarding its structure and function.
Early studies debated the glomerular-tubular connection, later confirmed by Bowman in 1842.
Ludwig proposed ultrafiltration as the glomerular filtration mechanism.

Purpose of the Study:

To review the historical context of renal glomerulus structure and function.
To analyze conflicting findings on glomerular filtration dynamics and equilibrium.
To discuss implications for human kidney physiology.

Main Methods:

Historical review of anatomical and physiological studies.
Analysis of experimental data on ultrafiltration coefficient (Kf) and glomerular filtration rate (GFR).

Related Experiment Videos

Comparison of filtration dynamics across different species (rats, dogs, monkeys).

Main Results:

Conflicting data exist on filtration pressure equilibrium in rat glomeruli, with varying Kf and GFR dependence on plasma flow.
Studies in Munich-Wistar rats show either filtration equilibrium (Kf=0.08) or disequilibrium (Kf=0.04).
Filtration disequilibrium is reported in dogs, while equilibrium is observed in squirrel monkeys.

Conclusions:

Glomerular filtration dynamics vary between species and even within rat strains.
Human kidney filtration is predicted to exhibit disequilibrium, but further direct measurements are needed.
Understanding these dynamics is crucial for renal physiology and disease research.