Related Experiment Video
Updated: Jun 25, 2025
Modeling the Functional Network for Spatial Navigation in the Human Brain
Published on: October 13, 2023
Connectome-based schizophrenia prediction using structural connectivity - Deep Graph Neural Network(sc-DGNN)
1School of Computer Science Engineering and Information Systems, Vellore Institute of Technology, Vellore, India.
Background:
Connectome is understanding the complex organization of the human brain's structural and functional connectivity is essential for gaining insights into cognitive processes and disorders.
Objective:
To improve the prediction accuracy of brain disorder issues, the current study investigates dysconnected subnetworks and graph structures associated with schizophrenia.
Method:
By using the proposed structural connectivity-deep graph neural network (sc-DGNN) model and compared with machine learning (ML) and deep learning (DL) models.This work attempts to focus on eighty-eight subjects of diffusion magnetic resonance imaging (dMRI), three classical ML, and five DL models.
Result:
The structural connectivity-deep graph neural network (sc-DGNN) model is proposed to effectively predict dysconnectedness associated with schizophrenia and exhibits superior performance compared to traditional ML and DL (GNNs) methods in terms of accuracy, sensitivity, specificity, precision, F1-score, and Area under receiver operating characteristic (AUC).
Conclusion:
The classification task on schizophrenia using structural connectivity matrices and experimental results showed that linear discriminant analysis (LDA) performed 72% accuracy rate in ML models and sc-DGNN performed at a 93% accuracy rate in DL models to distinguish between schizophrenia and healthy patients.
